CETIS

Comprehensive Environmental Toxicity Information System

Analyze, maintain, share and organize complex toxicity data in one application.

In use at 290+ labs & agencies
U.S. EPAU.S. Geological SurveyEnvironment CanadaWA Dept. of Ecology

No other specialized toxicity software puts this much analysis, database, and reporting in one application

CETIS analyzes, maintains, and organizes complex, heterogeneous toxicity data from freshwater, estuarine, marine, and terrestrial tests, across the spectrum of effluents, ambient water, aerosols, reference toxicants, and sediment.

Much of the analysis can be automated: build decision-tree logic to match your regulatory authority (the U.S. EPA or Environment Canada) so automated calculations flow into NOEL/LOEL estimates. The result is fast and consistent.

Surface & receiving waters, effluent & reference toxicants, liquid, solids & aerosols, all explored in detail below.

At a glance
Platform Microsoft Access (Windows)
Statistical methods 100+ tests & models
Standards U.S. EPA · Env. Canada · OECD
Validated against R · EPA Probit · SAS
Deployment Multi-user, networked
CETIS Developer Tidepool Scientific, LLC
Licensing Platform QLM by Soraco Technologies
See editions & pricing →

Built for the full range of toxicity testing

Surface and receiving waters, effluent and lab samples, solids and aerosols: CETIS handles heterogeneous toxicity data across every medium your lab tests.

Surface & receiving waters

Surface & receiving waters

Freshwater · Estuarine · Marine · Ambient Water
Effluent & lab

Effluent & lab

Effluents · Reference Toxicants
Solids & air

Solids & aerosols

Terrestrial · Sediment · Soils · Aerosols

CETIS is method-driven and adapts to other media as your program requires.

From statistical analysis to
regulatory-grade documentation

Every method, decision, and export stays traceable in one database file.

Gunther Du Hoffman Head of Statistics
Eurofins Agroscience Services
“As a biostatistician with over a decade in regulatory ecotoxicology, I’ve relied on CETIS as a cornerstone tool for statistical analysis and data interpretation. It consistently delivers the reliability, flexibility, and regulatory-grade documentation we need for submissions to EPA, OECD, and other agencies, seamlessly supporting replicate-based analysis, monotonicity evaluations, NOEC/LOEC determinations, and ECx/LCx modeling. What stands out most is how well it balances technical rigor with practical usability: when data deviates from monotonic assumptions, or professional judgment is required to weigh statistical significance against biological relevance, the software makes it straightforward to document those decisions transparently. The integrated database and export capabilities have saved our team considerable time while ensuring full traceability for QA reviews and regulatory scrutiny. In my experience, CETIS is not just another software package — it is a trusted partner that helps our laboratory meet the highest standards of scientific integrity and regulatory compliance. I highly recommend its continued use for all relevant ecotoxicology programs. Our team’s confidence in our statistical outputs has only grown since incorporating it more deeply into our standard processes.”
01 Analyze

The widest statistical method set in one application

More than 40 hypothesis tests and 40 regression models: the methods you are required to run, integrated in one place. Decision-tree logic selects the method and verifies every assumption, and you can override any decision.

Decision-tree logic

Automates method selection and assumption checking per jurisdiction. Override any decision at any step.

Matches your regulatory authority

CETIS changes its decision rules per jurisdiction, and it’s the only software that fully supports the 2005 Environment Canada Guidance Document on Statistical Methods for Environmental Toxicity Tests.

EPA · EC · OECD

Implements statistical methods described by the U.S. EPA, Environment Canada (2005), and OECD, including WET review and test acceptability criteria.

Verified to 6 sig figs

Every procedure validated against R or U.S. EPA published programs. Results judged identical to the 6th significant figure or better against EPA Probit, SAS, and S-Plus.

See it in CETIS
Set up the desired analysis and CETIS generates the results and plots, all selectable from tabs.
CETIS · Concentration–Response Analysis 01 / 05 · ENLARGE ⤢

Set up the desired analysis and CETIS generates the results and plots, all selectable from tabs.

CETIS · Concentration–Response Analysis
Set up the desired analysis and CETIS generates the results and plots, all selectable from tabs.
Set up the desired analysis and CETIS generates the results and plots, all selectable from tabs.
Method library
Search for any statistical method available in CETIS
No methods match that search.
96 methods · 11 families · 2 groups
02 Maintain

A secure, structured database instead of scattered files

A split front-end / back-end design on the Microsoft Access file-server platform, with advanced filtering and querying, plotting, and data-integrity tracking.

QC plots

Levey-Jennings (Shewhart), Cumulative Mean, and Cusum plots, intra- or inter-laboratory, for any point estimate, NOEL, LOEL, PMSD, or control response.

Networking & security

Licensed front-end copies on each workstation share one server-based database, with Microsoft Access user-level security managing access to the application and the data.

Serial-port instrument capture

Interface probes, balances, and other instruments directly to the data-entry screens to eliminate transcription errors and speed measurement recording.

Import & export

Move records between CETIS databases, including exports to a central authority that maintains a master copy of a database.

See it in CETIS
Every test in the database displayed in one global list, filterable and sortable so any record is a click away.
CETIS · Test List 01 / 05 · ENLARGE ⤢

Every test in the database displayed in one global list, filterable and sortable so any record is a click away.

CETIS · Test List
Every test in the database displayed in one global list, filterable and sortable so any record is a click away.
Every test in the database displayed in one global list, filterable and sortable so any record is a click away.
Split file-server design Microsoft Access platform
Front-end · per workstation
CETIS.accde
CETISx64.accde

Interface, forms, reports, and analysis tools. A licensed copy runs on each workstation. Both 32-bit and 64-bit versions of the front-end are provided.

Linked
tables
Back-end · shared on server
CETIS.accdb

All data, indexes, relationships, and records in one database, shared across every licensed workstation on the network. Back-end diagnositics, repair and compaction utilities can verify structural integrity of your database and rebuild indexes and relationships as needed, insuring your database functions normally and efficiently.

Entered once

A test batch applies to one or more samples tested the same day with the same species under the same conditions, so a sample’s details are entered once and associated with as many test batches as needed. This design increases efficiency and insures a normalized database.

03 Organize

Reports and deliverables, ready to send

Publication-quality reports, control charts, and electronic data deliverables, customizable down to the endpoint and ready for multi-jurisdictional review.

Reports & deliverables

Publication-quality reports, control charts, and electronic data deliverables for individual analyses, summaries, and measurements.

WET Evaluation report

Assess a Whole Effluent Toxicity test against established IWC and acceptability criteria, and generate a finding-based cover letter with your agency or company logo.

Test Acceptability Criteria

Apply user-definable criteria to any test type: control response, control CV, PMSD, NOEL, LOEL, or measurements like temperature, pH, or salinity. CETIS flags whether results meet them.

Fully customizable

From user-definable lists (materials, species, protocols) to entirely new test layouts and endpoints, all shipped with extensive, editable defaults.

Effluents & reference toxicants

Single-sample dilution tests, supported end to end from test setup through reporting.

Sediment & ambient water

Multiple-sample designs are supported end to end in CETIS, from test setup to reporting.

See it in CETIS
Choose the analyses, endpoints, and effect levels each report generates, then create, display and print the report in one pass.
CETIS · Test Reports 01 / 03 · ENLARGE ⤢

Choose the analyses, endpoints, and effect levels each report generates, then create, display and print the report in one pass.

CETIS · Test Reports
Choose the analyses, endpoints, and effect levels each report generates, then create, display and print the report in one pass.
Choose the analyses, endpoints, and effect levels each report generates, then create, display and print the report in one pass.
In regulatory practice

Agencies can electronically receive data from CETIS labs, review it for compliance, and issue letters of non-compliance to permittees. The Washington State Department of Ecology runs an electronic WET data-submittal and review system built chiefly on CETIS.

“CETIS has simplified WET data management at every step. I could not do my job nearly as well without it.”
Randall Marshall — WET Coordinator, WA Department of Ecology

Common questions

Post-sale and technical questions live on Support.

You need to know almost nothing about SQL; CETIS does the work behind the scenes. The more you learn about Access, the more you can apply, but very little is required to use CETIS successfully.

Labs have reported that CETIS takes less than one-tenth the time of traditional solutions to input and analyze toxicity data. For a lab processing 500 samples per year at $30/hour, that can represent roughly $15,000 in annual savings.

Yes. You can run CETIS with the free Microsoft Access runtime (2016 or higher). Having at least one full copy of Access is recommended for editing the back-end database if needed.

Yes. CETIS supports single-sample dilution tests (effluents, reference toxicants) and multiple-sample designs (sediment, ambient water), from test setup through reporting.

CETIS has been integrated with the ChemWare Horizon LIMS for a regional client, and Tidepool can provide custom programming to integrate CETIS with your LIMS. Contact us for a quote.

Yes. CETIS ships with a free utility that converts a ToxCalc 5.0 database to the CETIS format, and Tidepool offers a conversion service.

Operating system Windows 10 or 11
Microsoft Access 32- or 64-bit Access 2016+, Microsoft 365 with Access, or the 2016+ runtime
Memory 8 GB minimum · 16 GB recommended
Disk space 5 GB available
Processor Core i3, i5, i7, or higher
Printer High-resolution laser recommended for reports & graphics

See it against your own data

We’ll walk your team through CETIS on a real dataset and put together a quote for your lab or program.

Request a walkthrough See pricing